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[edit] Schematic

Thyroid Schematic

• Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones
• Understanding Local Control of Thyroid Hormones: (Deiodinases Function and Activity)
• Low-T3 Syndrome A Strong Prognostic Predictor of Death in Patients With Heart Disease
• Thyroid Hormone Treatment to Mend a Broken Heart

[edit] Thyroid factoids

• Thyroid has an effect on most every part of our bodies.

• The discovery that extracts of animal thyroid tissue could cure hypothyroidism was in 1892

• At one time iodine was used to treat hypothyroidism (Why was it stopped when replacement therapy became the norm?)

• Armour does not contain human T4 or T3 - it is similar enough to work well.

• There is NO consensus on how to treat hypothyroidism - even among endocrinologists.

• The T3 in Armour is IR - and will cause a bump in Free-T3 serum levels - this kick may account for (some of?) the preference.

• Armour also contain T2 and many other things(perhaps iodine?) - some of which may also be lacking in hypothyroid folks.

• A very few people do get allergic reactions to Armour.

• T4 and T3 prescriptions are supposed to be exactly the same thing our bodies make.

• T3 is somewhat unstable at higher temperatures (including the T3 in Armour).

• Our thyroid gland makes 20% T3

• The regulation system for thyroid is one of the most precise in nature - keeps T4 and Free-T3 nice and constant.

• Some tissues cannot convert T4 to T3 - most can (the brain has problems here)

• In order to simulate nature - T3 needs to be given slow release - which eliminates any morning 'kick' from the med - no studies exist to see if it might help the wide number of systems it effects.

• Armour can also be given slow release - no studies exist that I know of.

• Studies comparing T4 vs T4 + T3 have varied results - and are of very poor quality design. The biggest study seems inconclusive (not exactly well designed) . (Little is known of effects on LDL sub-fractions and Lp(a)). They noted that people somewhat preferred T4 + T3 but could not measure why (depression and anxiety scales - cognitive scales etc didn't account for it).

• There is an insane lack of good research on optimizing hypothyroid treatment.

• Some people report improvement when switched to Armour - some the opposite. Most often people are taking T4 mono-therapy - and get T3 if they switch to Armour which might account for some of the difference. Switching to Armour from T4+T3 is not likely to result in exactly the same dose or ratio. Quality studies don't exist.

• There are no patents waiting so research funding is unlikely.

• Both to little Thyroid hormone AND too much can result in depression.

• Insulin and T3 interact with each other.

• We don't know the optimal dose of iodine - studies have not been done - no patent possibilities?

• Extremely high and low TSH are indicative of low and high thyroid - it is not clear that intermediate numbers mean that much.

• This study, while interesting - is still a combination of several poor quality studies - not sure what it could possibly mean. Effect of combination therapy with thyroxine (T4) and 3,5,3-triiodothyronine (T3) versus T4 mono-therapy in patients with hypothyroidism, a double blind, randomized cross-over study. Mixing several poor quality soups together will not often result in a great soup.. ..

• My hunch is it seems best to take T4 + SRT3 or SR-Armour - perhaps much better if divided twice a day. No studies to back up or refute my hunch. I also think that Free-T3 is the number to tweak - I could be wrong.